DAMPAK PENGAWET PARABEN TERHADAP KESEHATAN MANUSIA: LITERATURE REVIEW
DOI:
https://doi.org/10.33651/jpkik.v8i2.422Keywords:
paraben, preservative, human health impact.Abstract
Parabens are one of the most common preservatives used in products circulating in the community. Parabens are used not only alone but can be combined with other parabens. Parabens can enter the human body through the skin and parenterally. Average total daily paraben exposure is estimated at 76 mg, with cosmetics and personal care products reaching 50 mg, 25 mg from pharmaceutical products, and 1 mg from food. Based on BPOM regulation Number 18 of 2015 concerning technical requirements for preservatives, the limit for single parabens used is 0.14% and mixed parabens is 0.8%. If it exceeds these provisions, it will cause skin irritation and allergies. The method in this research is a literature study sourced from Google Scholar and Pubmed with the year of publication of the literature for the last 10 years in the range of 2012 to 2022. The results of this study discuss how the impact of parabens on human health is found that parabens have a role in obesity, increased asthma reports, affect the menstrual cycle, genotoxic effects, cytotoxic effects, and breast.
References
Garner, N., Siol, A., & Eilks, I. (2014). Parabens as preservatives in personal care products. Chemistry in Action, 103, 36-43.
Dodge, L. E., Kelley, K. E., Williams, P. L., Williams, M. A., Hernández-Díaz, S., Missmer, S. A., & Hauser, R. (2015). Medications as a source of paraben exposure. Reproductive toxicology, 52, 93-100.
Petric, Z., Ruži?, J., & Žuntar, I. (2021). The controversies of parabens–an overview nowadays. Acta Pharmaceutica, 71(1), 17-32.
Kirchhof, M. G., & de Gannes, G. C. (2013). The health controversies of parabens. Skin Therapy Lett, 18(2), 5-7.
Mathiesen, L., Zuri, G., Andersen, M. H., & Knudsen, L. E. (2013). A proposed study on the transplacental transport of parabens in the human placental perfusion model. Alternatives to laboratory animals, 41(6), 473-482.
Rahmadani, R., El Rahma, I. S., & Amalia, P. R. (2021). Sosialisasi Bahaya Kandungan Paraben pada Kosmetik. JPKMI (Jurnal Pengabdian Kepada Masyarakat Indonesia), 2(3), 209-214.
Obat, B. P. (2015). Peraturan kepala Badan Pengawas Obat dan Makanan Republik Indonesia nomor 18 tahun 2015 tentang persyaratan teknis bahan kosmetika.
Hu, P., Chen, X., Whitener, R. J., Boder, E. T., Jones, J. O., Porollo, A., ... & Zhao, L. (2013). Effects of parabens on adipocyte differentiation. Toxicological sciences, 131(1), 56-70.
Kolatorova, L., Sramkova, M., Vitku, J., Vcelak, J., Lischkova, O., Starka, L., & Duskova, M. (2018). Parabens and their relation to obesity. Physiological Research, 67, S465-S472.
Quirós-Alcalá, L., Hansel, N. N., McCormack, M. C., & Matsui, E. C. (2019). Paraben exposures and asthma-related outcomes among children from the US general population. Journal of Allergy and Clinical Immunology, 143(3), 948-956.
Nishihama, Y., Yoshinaga, J., Iida, A., Konishi, S., Imai, H., Yoneyama, M., ... & Shiraishi, H. (2016). Association between paraben exposure and menstrual cycle in female university students in Japan. Reproductive Toxicology, 63, 107-113.
Güzel Bayülken, D., & Ayaz Tüylü, B. (2019). In vitro genotoxic and cytotoxic effects of some paraben esters on human peripheral lymphocytes. Drug and Chemical Toxicology, 42(4), 386-393.
Amin, M. M., Tabatabaeian, M., Chavoshani, A., Amjadi, E., Hashemi, M., Ebrahimpour, K., ... & Mansourian, M. (2019). Paraben content in adjacent normal-malignant breast tissues from women with breast cancer. Biomedical and Environmental Sciences, 32(12), 893-904.
Blüher, M., & Mantzoros, C. S. (2015). From leptin to other adipokines in health and disease: facts and expectations at the beginning of the 21st century. Metabolism, 64(1), 131-145.
Sramkova, M., Duskova, M., Vitku, J., Vcelak, J., Matucha, P., Bradnova, O., ... & Starka, L. (2015). Levels of adipokines and some steroids during the menstrual cycle. Physiological research, 64, S147.
Rahmawati, A. (2014). Mekanisme Terjadinya Inflamasi Dan Stres Oksidatif Pada Obesitas. El-Hayah, 5(1), 1-8.
Welan, R., Revilla, G., & Desmawati, D. (2018). Korelasi persentase lemak tubuh dengan kadar adipsin pada premenopause. Jurnal Gizi Klinik Indonesia, 14(3), 99-106.
Lee-Sarwar, K., Hauser, R., Calafat, A. M., Ye, X., O'Connor, G. T., Sandel, M., ... & Savage, J. H. (2018). Prenatal and early-life triclosan and paraben exposure and allergic outcomes. Journal of Allergy and Clinical Immunology, 142(1), 269-278.
Hazanah, S. (2017). Hubungan Stress Dengan Siklus Menstruasi pada Usia 18-21 tahun. Husada Mahakam: Jurnal Kesehatan, 3(7), 331-339.
Sofiakmi, R. L. Q., Ulfah, M., & Sasmito, E. (2014). Uji Aktivitas Imunomodulator Fermentasi Teh Hitam Jamur Kombucha Terhadap Roliferasi Sel Limfosit Mencit Galur Balb/c Secara in Vitro. Jurnal Ilmu Farmasi dan Farmasi Klinik, 130-138.
Lillo, M. A., Nichols, C., Perry, C., Runke, S., Krutilina, R., Seagroves, T. N., ... & Krum, S. A. (2017). Methylparaben stimulates tumor initiating cells in ER+ breast cancer models. Journal of Applied Toxicology, 37(4), 417-425.
Pan, S., Yuan, C., Tagmount, A., Rudel, R. A., Ackerman, J. M., Yaswen, P., ... & Leitman, D. C. (2016). Parabens and human epidermal growth factor receptor ligand cross-talk in breast cancer cells. Environmental health perspectives, 124(5), 563-569.
Published
How to Cite
Issue
Section
JPKIK : Jurnal Peneliian dan Kajian Ilmiah kesehatan is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License
You are free to :
Share — copy and redistribute the material in any medium or format
Adapt — remix, transform, and build upon the material for any purpose, even commercially
Under the following terms :
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original
No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits
